General information of collected datasets during cell state transitions:
Transitions (Click to analyse) |
Technology |
Species |
Origin cell |
Intermediate time points |
Terminal cell |
Induction |
Data source |
---|---|---|---|---|---|---|---|
GSE32658.LSB | microarray | Homo sapiens | ESC | D1, D3, D5, D7, D11, D13, D25 | Neuron | L(LDN193189(BMP inhibitor)), SB(SB431542 (TGF-b signal inhibitor)) | GSE32658 |
GSE32658.LSB.S.F8 | microarray | Homo sapiens | ESC | D3, D5, D7, D11, D13, D25 | Neuron | L(LDN193189(BMP inhibitor)), (SB431542 (TGF-b signal inhibitor)), S (SHH + Purmorphamine (Smo agonist)), F8 (FGF8) | GSE32658 |
GSE32658.LSB.S.F8.CHIR | microarray | Homo sapiens | ESC | D5, D7, D11, D13, D25 | Neuron | L(LDN193189(BMP inhibitor) , day 0-11), (SB431542 (TGF-b signal inhibitor), day 0-5), S (SHH + Purmorphamine (Smo agonist), day 1-7), F8 (FGF8, day 1-7) and CHIR (CHIR99021 (GSK3b inhibitor), day 3-13) | GSE32658 |
GSE44303 | microarray | Homo sapiens | MSC | D0.021, D0.042, D0.083, D0.25, D0.5, D1, D1.5, D7, D14 | PreADP | IBMX, indomethacin, dexamethasone, insulin; Lonza, PT-3102B/PT-4135 | GSE44303 |
GSE67152.D1.and.D2 | microarray | Homo sapiens | ESC | D1, D2, D3, D4, D5, D6, D8 | CM | BMP4, CHIR99021, Dorsomorphin, IWP-2 on days 1 and 2 | GSE67152 |
GSE67152.D2.and.D3 | microarray | Homo sapiens | ESC | D1, D2, D3, D4, D5, D6, D8 | CM | BMP4, CHIR99021, Dorsomorphin, IWP-2 on days 2 and 3 | GSE67152 |
GSE42094 | microarray | Homo sapiens | ESC | D3, D7, D11, D15, D18 | Pancreatic Beta Islet Cell | According to D'Amour et al., 2006 with minor modifications: 1% BSA and 1% NEAA were added in the first 3 days of treatment to increase cell viability. | GSE42094 |
GSE50206.MEF | microarray | Mus musculus | MEF | D3, D7, D11, D15, D20, D24 | iPSC | OCT3/4, SOX2, KLF4, c-MYC and GLIS1 | GSE50206 |
GSE12985.E3.5 | microarray | Mus musculus | TSC | D1, D2, D3, D4, D5, D6 | TSC_unknown | withdrawal of FGF4 heparin and feeder conditioned medium | GSE12985 |
GSE12985.E6.5 | microarray | Mus musculus | TSC | D1, D2, D3, D4, D5, D6 | TSC_unknown | withdrawal of FGF4 heparin and feeder conditioned medium | GSE12985 |
GSE46532 | microarray | Mus musculus | MEF | D11, D15, D19, D22, D26 | iPSC | Oct4,cMyc,Klf4 | GSE46532 |
GSE5671 | microarray | Mus musculus | ESC | D5, D6, D7, D8 | CM | through EB formation | GSE5671 |
GSE4818 | microarray | Mus musculus | ESC | D11, D12, D14, D16, D18 | Testis | removed from fetuses | GSE4818 |
GSE5334 | microarray | Mus musculus | ESC | D11, D12, D14, D16, D18 | Ovary | removed from fetuses | GSE5334 |
GSE21278 | microarray | Mus musculus | ESC | E10, E11, E12, E13, E14, E15, E16, E17, E18 | Hypothalamus | obtain from embryo | GSE21278 |
GSE16992 | microarray | Mus musculus | Myoblast | D0.021, D0.042, D0.063, D0.083, D0.125, D0.15, D0.375, D0.5, D1, D2, D4, D6 | Myotube | DMEM + 2% horse serum | GSE16992 |
GSE6881 | microarray | Mus musculus | ESC | E11.5, E12.5, E14.5, E16.5, E18.5 | Testis | obtain from embryo | GSE6881 |
GSE6882 | microarray | Mus musculus | ESC | E11.5, E12.5, E14.5, E16.5, E18.5 | Ovary | obtain from embryo | GSE6882 |
GSE36313.ESC | microarray | Mus musculus | ESC | D0.125, D0.25, D0.5, D1, D2, D3 | Endoderm Cell | Gata4GR | GSE36313 |
GSE36313.Mesoderm | microarray | Mus musculus | Mesoderm Cell | D0.5, D1, D1.5, D2, D3 | Endoderm Cell | Gata4GR | GSE36313 |
GSE50206.HDF | microarray | Homo sapiens | HDF | D3, D7, D11, D15, D20, D28, D35, D42, D49 | iPSC | OCT3/4, SOX2 (IRES-EGFP), KLF4 and c-MYC | GSE50206 |
GSE50206.ASC | microarray | Homo sapiens | ASC | D3, D7, D11, D20, D28 | iPSC | OCT3/4, SOX2 (IRES-EGFP), KLF4 and c-MYC | GSE50206 |
GSE50206.Astrocyte | microarray | Homo sapiens | Astrocyte | D3, D7, D11, D15, D20, D28, D35, D42 | iPSC | OCT3/4, SOX2 (IRES-EGFP), KLF4 and c-MYC | GSE50206 |
GSE50206.NHBE | microarray | Homo sapiens | NHBE | D3, D7, D11, D15, D28 | iPSC | OCT3/4, SOX2 (IRES-EGFP), KLF4 and c-MYC | GSE50206 |
GSE50206.PrEC | microarray | Homo sapiens | PrEC | D3, D7, D11, D15, D28 | iPSC | OCT3/4, SOX2 (IRES-EGFP), KLF4 and c-MYC | GSE50206 |
GSE2154 | microarray | Mus musculus | Embryo Limb Bud | D3, D6, D9, D12, D15 | Chondrocyte | beta-glycerophosphate and ascorbic acid | GSE2154 |
GSE75582 | microarray | Homo sapiens | ESC | D8, D9, D12, D15 | Neuron | Immature dorsal root ganglia neurons have been generated as described in Chambers SM, Qi Y, Mica Y, et al. Cryopreserved 8 days differentiated cells, then continue differentiation after thawing | GSE75582 |
GSE10315.TGFb3 | microarray | Homo sapiens | MSC | D1, D3, D7, D21 | Chondrocyte | TGFβ3 | GSE10315 |
GSE51533.PIP | microarray | Homo sapiens | ESC | D1, D3, D5, D7, D9, D11 | Neuroepithelial Cell | use dual-SMAD inhibition protocol to differentiate towards CNS lineages then remove Noggin at day3 (PIP protocal) | GSE51533 |
GSE51533.NSB | microarray | Homo sapiens | ESC | D1, D3, D5, D7, D9, D11 | Neuroepithelial Cell | N-SB protocol | GSE51533 |
GSE14387 | microarray | Mus musculus | Myoblast | D0.007, D0.014, D0.021, 0.042, D0.104, D0.15, D0.25 | Myotube | differentiation medium (DMEM with 2% FBS, 2% Glutamax, 1% glucose and penicillin/streptomycin) | GSE14387 |
GSE28191 | microarray | Homo sapiens | iPSC | D2, D5, D7, D9 | CM | RPMI+B27 medium | GSE28191 |
GSE34551 | microarray | Homo sapiens | ESC | D2, D3, D5, D7 | Neuron | KSR media + N2 media(5d) | GSE34551 |
GSE54766 | microarray | Homo sapiens | iPSC | D7, D14, D21, D28, D35 | MSC | OCT3/4, SOX2, KLF4, and c-MYC | GSE54766 |
GSE10469.O4percent | microarray | Homo sapiens | ESC | D0.125, D0.5, D1, D3, D5 | Trophoblast | FGF2-,different oxygen conditions:4% | GSE10469 |
GSE10469.O20percent | microarray | Homo sapiens | ESC | D0.125, D0.5, D1, D3, D5 | Trophoblast | FGF2-,different oxygen conditions:20% | GSE10469 |
GSE12531 | microarray | Homo sapiens | ESC | D3, D5, D7, D10 | Primitive Hemangioblast | serum free conditions in the presence of BMP4,VEGF,and FGF2 | GSE12531 |
GSE37761.O5percent | microarray | Homo sapiens | ESC | D0.5, D1, D5, D10, D15 | Endothelial Cell | oxygen levels:1% using foreskin-fibroblast conditioned medium | GSE37761 |
GSE37761.O21percent | microarray | Homo sapiens | ESC | D0.5, D1, D5, D10, D15 | Endothelial Cell | oxygen levels: 5% using foreskin-fibroblast conditioned medium | GSE37761 |
GSE37836 | microarray | Homo sapiens | MSC | D0.042, D0.5, D1, D2, D4, D6, D9, D12, D15 | Adipocyte | Adipogenic induction medium( 2ml of human-insulin, 1ml of dexamethasone, and 0.4ml of indomethacin and 0.2ml of IBMX) | GSE37836 |
GSE56988 | microarray | Mus musculus | NSC | D1, D2, D4, D7 | Neuron | differentiation medium(DMEM/F12/N2 – Invitrogen, 2% FCS - Hyclone, 20 ng ml-1 bFGF, 35 μg ml-1 bovine pituitary extract – Peprotech) | GSE56988 |
GSE19044.ESC | microarray | Mus musculus | ESC | D2, D7, D14, D21, D28 | Hepatocyte | hepatic differentiation cocktail | GSE19044 |
GSE46328 | microarray | Homo sapiens | EPC | D5, D7, D9, D13, D17 | Endothelial Cell | GSE46328 | |
GSE41352 | microarray | Homo sapiens | Preadipocyte | D0.167, D0.333, D0.5, D1, D3, D12 | Adipocyte | OF media(0.01 mg/ml human transferrin, 200 nM T3, 100 nM cortisol, 20 nM insulin, 500 microM IBMX and 100 nM rosiglitazone) | GSE41352 |
GSE49987.Myeloid | microarray | Mus musculus | FDCP | D0.083, D0.167, D0.25, D0.333, D0.417, D0.5, D0.583, D0.667, D0.75, D0.833, D0.917, D1, D1.125, D1.25, D1.375, D1.5, D1.625, D1.75, D1.875, D2, D2.167, D2.333, D2.5, D2.667, D2.833, D3, D4, D5, D7 | Myeloid | IMDM plus 10% FCS and low IL-3 supplemented with either Epo and SCF | GSE49991 |
GSE49987.Erythroid | microarray | Mus musculus | FDCP | D0.083, D0.167, D0.25, D0.333, D0.417, D0.5, D0.583, D0.667, D0.75, D0.833, D0.917, D1, D1.125, D1.25, D1.375, D1.5, D1.625, D1.75, D1.875, D2, D2.167, D2.333, D2.5, D2.667, D2.833, D3, D4, D5, D7 | Erythroid | IMDM plus 10% FCS and low IL-3 supplemented with either Epo and hemin or G-CSF | GSE49991 |
GSE628 | microarray | Mus musculus | G1E | D0.125, D0.292, D0.583, D0.875, D1.25 | Erythroblast | Estradiol | GSE628 |
GSE43955 | microarray | Mus musculus | T Cell | D0.021, D0.042, D0.083, D0.167, D0.25, D0.333, D0.417, D0.5, D0.667, D0.833, D1, D1.25, D1.75, D2, D2.083, D2.167, D2.5, D3 | Th17 | 2ng/mL rhTGF-β1 (Miltenyi Biotec), 25ng/mL rmIl-6 (Miltenyi Biotec), 20ng/ml rmIl-23 (Miltenyi Biotec), and 20ng/ml rmIL-β1 (Miltenyi Biotec) | GSE43955 |
GSE43969 | microarray | Mus musculus | T Cell | D1, D2, D2.042, D2.25, D2.708, D3 | Th17 | 2ng/mL rhTGF-β1 (Miltenyi Biotec), 25ng/mL rmIl-6 (Miltenyi Biotec), 20ng/ml rmIl-23 (Miltenyi Biotec), and 20ng/ml rmIL-β1 (Miltenyi Biotec) | GSE43969 |
GSE6932 | microarray | Homo sapiens | EPC | D0.5, D1, D1.5, D2 | NHEK | PP-2 (compound 9) | GSE6932 |
GSE5264.donor1 | microarray | Homo sapiens | HBEC | D1, D2, D4, D8, D10, D12, D14, D17, D21, D28 | Mucociliary Cell | 500 nM retinoic acid was added to culture medium after cells reached 100% confluence to promote differentiation. Air-liquid interface (ALI) culture was initiated 48 hours later by removing the apical medium, and basolateral media containing 100nM retinoic acid was used for the ALI culture period. | GSE5264 |
GSE5264.donor2 | microarray | Homo sapiens | HBEC | D1, D2, D4, D8, D10, D12, D14, D17, D21, D28 | Mucociliary Cell | 500 nM retinoic acid was added to culture medium after cells reached 100% confluence to promote differentiation. Air-liquid interface (ALI) culture was initiated 48 hours later by removing the apical medium, and basolateral media containing 100nM retinoic acid was used for the ALI culture period. | GSE5264 |
GSE5264.donor3 | microarray | Homo sapiens | HBEC | D1, D2, D4, D8, D10, D12, D14, D17, D21, D28 | Mucociliary Cell | 500 nM retinoic acid was added to culture medium after cells reached 100% confluence to promote differentiation. Air-liquid interface (ALI) culture was initiated 48 hours later by removing the apical medium, and basolateral media containing 100nM retinoic acid was used for the ALI culture period. | GSE5264 |
GSE1984 | microarray | Mus musculus | Myoblast | D0.167, D0.5, D1, D2 | Myotube | trichostatin A(TSA) | GSE1984 |
GSE69321 | microarray | Mus musculus | ESC | D0.5, D1, D1.5, D2, D4, D6 | Extroembryonic Endoderm Stem Cell | short pulse of Gata6 induction | GSE69321 |
GSE46321.withCEBPa | microarray | Mus musculus | B-cell | D0.125, D0.25, D0.5, D1, D2, D4, D6, D8 | iPSC | a pulse of C/EBPα in B cell precursors followed by OSKM expression | GSE46321 |
GSE46321.withoutCEBPa | microarray | Mus musculus | B-cell | D0.125, D0.25, D0.5, D1, D2, D4, D6, D8 | iPSC | a pulse of C/EBPα in B cell precursors followed by OSKM expression | GSE46321 |
GSE45223.Neural Lineage | microarray | Homo sapiens | ESC | D1, D3, D6, D8, D11 | Neural Lineage | Dual SMAD Inhibition (Dsi) | GSE45223 |
GSE45223.NC | microarray | Homo sapiens | ESC | D1, D3, D6, D8, D11 | NC | Dual SMAD Inhibition (Dsi) + CHIR 99021 | GSE45223 |
GSE45223.Melanocyte | microarray | Homo sapiens | ESC | D1, D3, D6, D8, D11 | Melanocyte | Dual SMAD Inhibition (Dsi) + CHIR99021 + BMP4 + EDN3 | GSE45223 |
GSE79146 | microarray | Mus musculus | MEF | D3, D7, D14 | Neuron | The chemical compound forskolin combined with Ascl1 | GSE79146 |
GSE71528 | microarray | Mus musculus | ESC | D2, D4, D5, D6, D8, D10 | CM | Grow as embryoid bodies, and transferred to tissue culture plates after 4.5 days [PMID:17360443] | GSE71528 |
GSE28688 | microarray | Homo sapiens | Fibroblast | D1, D2, D3 | iPSC | OSKM transduction | GSE28688 |
GSE11415 | microarray | Mus musculus | Myoblast | D0.25, D1, D2, D3, D4, D5 | Myotube | Culture cells in medium containing reduced serum concentration (2% v/v) for up to 5 days with medium changes every 2 days | GSE11415 |
GSE72676 | microarray | Homo sapiens | Fibroblast | D0.5, D0.7, D1, D1.2, D1.5, D1.7, D2, D2.2, D2.5, D2.7, D3.5, D3 | iPSC | SOX2,OCT3/4,c-MYC,KLF4 | GSE72676 |
GSE67995 | microarray | Homo sapiens | ESC | D1, D2, D3, D6, D10 | CM | Differentiation was induced upon replating cells on Matrigel-coated 24-well plates in a defined serum and serum albumin-free medium based on Knockout-DMEM | GSE67995 |
GSE67154 | microarray | Homo sapiens | ESC | D1, D2, D3, D4, D5, D6, D8 | CM | FGF (F) + BMP (B) + WNT (W) treatment during the first 24 hours | GSE67995 |
GSE35103 | microarray | Homo sapiens | T Cell | D0.021, D0.042, D0.083, D0.167, D0.25, D0.5, D1, D2, D3 | Th17 | IL6, IL1b and TGFb | GSE35103 |
GSE17806 | microarray | Mus musculus | Neuron | P7, P10, P15, P25, P40 | Postnatal Neuron | obtain from different postnatal day(P) interneuron | GSE17806 |
GSE14907 | microarray | Mus musculus | Embryonic Sweat Gland | E15.5, E16.5, E17.5, P1, P3, P5 | Postnatal Sweat Gland | obtain from different days during embryogenesis and postnatal(P) footpads | GSE14907 |
GSE37558.MSC | microarray | Homo sapiens | MSC | D2, D8, D12, D25 | Osteoblast | Osteogenic differentiation medium: 5 mM beta-glycerophosphate, 100 nM dexamethasone, 0.1 mM Vitamin C | GSE37558 |
GSE19236 | microarray | Homo sapiens | Monocyte | D0.25, D0.75, D1.125, D1.75, D2.125, D2.75 | Dendritic Cell | 20U/ml IL-4, 280U/ml GM-CSF and 10% FCS | GSE19236 |
GSE11854 | microarray | Homo sapiens | Somitogenesis | 1 hr, 2 hr, 3 hr, 4 hr, 5 hr, 6 hr, 7 hr, 8 hr, 9 hr, 10 hr, 11 hr, 12 hr | Somitogenesis | In vitro model of somitogenesis using human fibroblasts | GSE11854 |
GSE7536 | microarray | Mus musculus | Embryonic Inner Ear | E9, E9.5, E10, E10.5.Cochlea, E11.Cochlea, E11.5.Cochlea, E12.Cochlea, E10.5.Vestibular organ, E11.Vestibular organ, E11.5.Vestibular organ, E12.Vestibular organ, E12.5.Cochlea, E13.Cochlea, E13.5.Cochlea, E14.Cochlea, E14.5.Cochlea, E15.Cochlea, E12.5.Utricle and 3 ampullae, E13.Utricle and 3 ampullae, E13.5.Utricle and 3 ampullae, E14.Utricle and 3 ampullae, E14.5.Utricle and 3 ampullae, E15.Utricle and 3 ampullae, E12.5.Saccule, E13.Saccule, E13.5.Saccule, E14.Saccule, E14.5.Saccule, E15.Saccule | Inner Ear | obtain from different days during embryonic inner ear development | GSE7536 |
GSE43155 | microarray | Mus musculus | Embryonic Cornea | E14.5, E15.5, E17.5, P3, P7, P14, P28;(P:postnatal day) | Cornea | obtain from different days during cornea development | GSE43155 |
GSE15585 | microarray | Mus musculus | Embryonic Inner Ear | VOT-E36 cell, D1, D2, D4, D7, D14 | Inner Ear | NA | GSE15585 |
GSE18290.Human | microarray | Homo sapiens | 1-cell | 2-cell, 4-cell, 8-cell, Morula | Blastocyst | obtain from embryo | GSE18290 |
GSE18290.Mouse | microarray | Mus musculus | 1-cell | 2-cell, 4-cell, 8-cell, Morula | Blastocyst | obtain from embryo | GSE18290 |
GSE41208 | microarray | Homo sapiens | B-cell | D3, D6, D13, D20, D41 | Plasma Cell | CD138+ Plasma cells sorted on CD138 and 7-AAD, generated in the upper compartment of a transwell system after 28 days of IL-6, IFN-α and supplemented media, with M2-10B4 in the lower compartment. | GSE41208 |
GSE37558.VSMC | microarray | Homo sapiens | VSMC | D2, D8, D12, D25 | Osteoblast | Osteogenic differentiation medium: 5 mM beta-glycerophosphate, 100 nM dexamethasone, 0.1 mM Vitamin C | GSE37558 |